Human IFN-Alpha 2b (Alpha 2) Protein
Catalog Number: 11105
- Human Interferon Alpha 2b recombinant protein expressed in E.coli.
- Lot-Specific Activity (Unit/ml) allows accurate amount of active protein is being used for each experiment
- 95% or greater purity with less than 1 EU/ug endotoxin
- Custom carrier-free bulk available upon request
$335.00
Product Info
IFN-Alpha 2 (Alpha 2b) is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family. The Type I IFN family has antiviral, anti-proliferative and natural killer cell activities.
Specifications
| Formulation | Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) |
|---|---|
| Molecular Weight | 19.3 kDa |
| Source | Human leukocyte interferon alpha 2b cDNA expressed in E.coli |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue |
| Bioactivity | Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV) |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
| Synonyms | Interferon alpha 2, IFNa2, IFN alpha2b, IFN alpha, IFN-a, interferon alpha, IFN alpha 2, IFN-a2, alpha interferon, interferon alfa, IFN alfa, interferon a, interferon alpha 2b, IFN alpha 2b, Type I interferon alpha, Type I IFN alpha |
| Accession Number | V00548 |
Tech Info & Data
Citations
14 Citations
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- Barer, L. et al., (2023), "Lipocalin-2 regulates the expression of interferon-stimulated genes and the susceptibility of prostate cancer cells to oncolytic virus infection", Euro. J. Cell Biol., DOI: 10.1016/j. ejcb.2023.151328 (link)
- Unali, G., et al., (2023), "Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity", EMBO J., e112234, PMID: 36970857, DOI: 10.15252/embj.2022112234 (link)
- Zhu,, G. et al., (2023),"Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2", J. Clin. Immunol., PMID: 36753016, DOI: 10.1007/s10875-023-01445-3 (link)
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- Odhams, et al. (2019). Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. Nature Communications, 15 pgs. PMID: 31092820. (link)
- He, et al. (2019). A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Reports. PMID: 30840887. (link)
- Petrillo, Carolina, et al. (2018). Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing in Human Hematopoietic Stem Cells. Cell Reports, 23 pgs. PMID: 30416070. (link)
- Zhang, Sen, et al. (2018). Up-Regulation of MicroRNA-203 in Influenza A Virus Infection Inhibits Viral Replication by Targeting DR1. Scientific Reports, 15 pgs. PMID: 29717211. (link)
- Kishimoto, Daiga, et al. (2018). Dysregulated Heme Oxygenase-1^(low) M2-Like Macrophages Augment Lupus Nephritis via Bach1 Induced by Type I Interferons. Arthritis Research & Therapy, 11 pgs. PMID: 29636091. (link)
- Mohamed, Abdel-Mohsen, et al. (2014). Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1 in vivo. PLOS One, 9 pgs. PMID: 25275557. (link)
- Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)
- Cheng, et al. (2011). Establishment, Characterization, and Successful Adaptive Therapy Against Human Tumors of NKG Cell, a New Human NK Cell Line. Cell Transplantation. PMID: 21669033. (link)
- Lee, et al. (2007). Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. Arthritis and Rheumatism. PMID: 17968925. (link)