Anti-Human IFN-Alpha, Sheep Serum (PAb)
Catalog Number: 31110
Sheep polyclonal antibody that neutralizes all Human IFN-Alpha subtypes and is suitable for Direct Binding ELISA
$345.00
Product Info
Specificity
Binds to and blocks biological activity of all human IFN-Alpha subtypes
Tested Applications
Neutralizes all Human Interferon Alpha subtypes (IFN-Alpha A, IFN-Alpha 2, IFN-Alpha B2, IFN-Alpha C, IFN-Alpha D[val114], IFN-Alpha F, IFN-Alpha G, IFN-Alpha H2, IFN-Alpha l, IFN-Alpha J1, IFN-Alpha K, IFN-Alpha 1[Ala114], IFN-Alpha 4b, IFN-Alpha WA)
Specifications
| Formulation | Supplied frozen as neat serum diluted in phosphate buffered saline (PBS) |
|---|---|
| Antigen | Mixture of recombinant human IFN alpha subtypes (IFNA2, IFNA8, IFNA10, IFNA1, IFNA21, IFNA5, IFNA14, IFNA17, IFNA7, IFNA6, IFNA4, and IFNA16) |
| Host Species | Sheep |
| Bioactivity | Measured by neutralization of interferon in cytopathic effect inhibition assay using A549 cells challenged with EMCV. |
| Storage | For retention of full activity store at -70oC or below and avoid repeated freeze/thaw cycles. |
| Antigen Synonyms | Interferon alpha, IFN alpha sheep polyclonal, IFN-a, interferon alpha sheep polyclonal, Leukocyte interferon, Leukocyte IFN, alpha interferon, interferon alfa, IFN alfa, interferon a, Type I interferon alpha, Type I IFN alpha |
Tech Info & Data
Citations
2 Citation
- Malle, L. et al., (2023), "Autoimmunity in Down's syndrome via cytokines, CD4T cells and CD11c+B cells", Nature, PMID: 36813963, DOI: 10.1038/s41586-023-05736-y (link)
- Ka, N-L., et al., (2022), "Type I IFN Stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer", Cell. Mol. Life Sci., 79(6):306, PMID: 35593921, DOI: 10.1007/s00018-022-04333-y (link)
References
- Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," J. Virol. 37, 755-758
- Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon," in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394
- Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology (S. Pestka, ed.), Academic Press, New York 119, 14-23